Manufacturing companies and industrial sectors are increasingly required to integrate sustainable practices into their operations in order to protect the environment and promote social welfare. The concept of Sustainable Supply Chain Management (SSCM) has attracted widespread attention from academics and business practitioners in the last 20 years to address sustainability challenges in the supply chains. However, the adoption of SSCM practices is challenging for many businesses. This study aims to empirically evaluate the drivers that influence the adoption of SSCM practices among the manufacturing companies of Dakshina Kannada, Karnataka. The drivers were identified from the literature and included in the research questionnaire of the study. The empirical data were collected using a structured research questionnaire from 217 manufacturing firms across the district and analyzed descriptively to determine the degree of influence of each driver. The findings show that both internal and external SSCM drivers substantially influence SSCM practices in the manufacturing sector of Dakshina Kannada. Particularly, government regulations and top management commitment are among the most influential drivers.