The learning design is the key to the success of blending learning. The current blend teaching practice is simple mixing of online and offline learning, which based on information technology, the combination of classroom teaching and online learning. The study found that the “seeming mixing” of pure technology has become an important factor hindering the effect of blend teaching. Focusing on “student centered”, this paper takes the project cost management course of Zhejiang University of Finance and Economics as an example to conduct design research and effect analysis on blend learning design. The blend learning mode proposed in this paper has the characteristics of combining online and offline, connecting theory and practice, flipping interaction between teachers and students, and breaking the limitation of time and space, which can stimulate students’ interest in learning and improve their comprehensive ability.