The cultivation of "craftsman spirit" of higher vocational students is an inevitable requirement of deepening vocational education reform and adapting to the enrollment expansion strategy of higher vocational colleges. Under the implementation of the strategy of making China strong in manufacturing, cultivating and carrying forward the spirit of craftsman requires higher vocational colleges to take the regional industry as the guidance and rely on the means of school-enterprise cooperation to carry out the production-study-research and teaching system in depth. Based on years of work practice, this paper expounds the concrete countermeasures of cultivating students' "craftsman spirit" in higher vocational colleges, so as to enhance the employment competitiveness of higher vocational students and promote the high-quality development of China's manufacturing industry.