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In current academic situation, more and more faculty is facing with the stressful career. It is critically significant for the sustainable development of faculty vitality. In this study, based on Faculty Vitality Index by IUSM, included three measurements: Professional Engagement (PE), Career Satisfaction (CS) the Productivity (CP), the purpose of this study is to investigate the relationship between expectation–disconfirmation and faculty vitality. It highlights that the expectation is directly influenced the faculty vitality. Additionally, the track of faculty has profound impact on the expectation. This research has provided a new insight into the variances in overall Faculty Vitality Index. Briefly, this study also suggested that equitable funding resource allocation, supportive academic peers and collegial work environment could be incentives power to enhance the positive relationship between expectation and faculty vitality.