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Cloud computing is the use of computing resources (hardware and software) that are delivered as a service over a network (typically the Internet) while E-Learning is the currently fashionable term used to describe the diverse use of information and communications technologies to support and enhance learning, teaching and assessment from resource based learning. E-learning system is a welcome idea in this modern day life, because the massive proliferation of affordable computers, Internet broadband connectivity and rich education content has created a global phenomenon in which information and communication technology (ICT) is being used to transform education. This paper merge cloud-computing and e-learning to presents the design and implementation of cloud-based e-learning platform for scientific subjects. We use the three core science subjects (physics, chemistry and biology) as test bed for this research work. The choice of programming language is PHP (Hypertext pre-processor) for server-side scripting, Action script and Macromedia-Flash for media content authoring and MySQL as the back-end database.